CoroQuil-Zn is a herbal drug formulation designed to block the binding of Coronavirus’s Spike “S” protein to the human ACE2 receptors. Therefore, it inhibits the virus from attaching to human ACE2 which is the primary entry point for Coronaviruses like SARS-CoV-2.
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If you have tested positive for Coronavirus SARS-CoV-2, you should start taking CoroQuil-Zn immediately. The sooner you take the medication after the first symptoms of COVID-19 infection, the better the efficacy. The drug can also be taken prophylactically. The dosage varies for COVID positive patients and others taking prophylactically.
If you have tested positive, the dosage is 2-2-2 for 14 days. That is, 2 capsules after each meal (within 20 minutes of the meal). For prophylactic usage, it depends on whether you have exposure to Coronavirus. If you are actively working with COVID patients, then the dosage is still 2-2-2. If not, the dosage is 1-1-1.
If you have recovered from COVID, your body has the antibodies to fight an infection caused by Coronavirus. Sometimes people
experience fatigue and lethargy even after testing COVID negative. CoroQuil-Zn helps to protect as the drug itself has some great
properties besides Zinc (which is a good supplement). CoroQuil-Zn helps in regulating the immune system and overall wellness.
Therefore, it is beneficial to take CoroQuil-Zn in all situations as there may be new variants of coronaviruses.
The vaccine helps your body fight the virus if you get infected. Vaccine and/or drugs do not guarantee one from contracting COVID,
especially considering that new variants of coronavirus may emerge. Hence if one contracts COVID after vaccination, CoroQuil-Zn will
still reduce the viral load by inhibiting the Spike protein of the Coronavirus from docking with the ACE2 receptor. Therefore, it is
beneficial to take CoroQuil-Zn to prevent infection in the first place.
We have done preclinical assays to assess the efficacy of CoroQuil-Zn against one of the mutations N501Y reported in the UK, Brazil and South Africa. We have found CoroQuil-Zn to be effective in that mutation. We have not done specific Clinical Trials for this mutation as things are evolving by the day. Vaccines (both mRNA vaccines and viral vector-based vaccines) are designed based on a particular sequence of SARS-CoV-2. As a result, the vaccines may have limited efficacy with certain variants (or mutations). Please read WHO guidelines to know more about the efficacy of vaccines against mutations.
Remdesivir, Favipiravir, and new investigative drug Molnupiravir, all act at the level of RdRp (replication). We have done preclinical
cell-based assays with a combination of CoroQuil-Zn and Remdesivir and found that in the presence of CoroQuil-Zn (in small
concentrations) the Remdesivir effect is enhanced multifold. No formal Clinical Study has been done as a combination therapy with
Remdesivir.
We have completed Phase 3 Clinical Trials of CoroQuil-Zn in mild and moderate COVID-19 patients as per the “AYUSH and ICMR guidelines for Pandemic Trials” and Ethics Committee standards and approvals with CTRI registration. CoroQuil-Zn resulted in significantly more RTqPCR negative patients compared to Standard of Care. In fact, 94.8% of the patients turned -ve on Day 7 and 100% of patients who took Coroqui-Zn turned negative on Day 14. It is currently awaiting approval by the Dept. of Ayush. The CTRI link is : http://ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=48763&EncHid=&modid=&compid=%2 7,%2748763det%27
CoroQuil-Zn is made entirely from edible plant extracts. No adverse events or side effects were encountered during the Phase 3 Clinical Trial. According to Ayurvedic Pharmacopoeia these plant extracts are within the permissible limits of consumption and not likely to produce any side effects.
To paraphrase Dr. Jitendra Mistry, GI Surgeon, Gangaram Hospital, New Delhi, it is actually more about evidence based medicine rather than these pathies. If something is effective and scientifically proven, it can be and should be prescribed. As an example, Isabgol is a natural medicine. It is scientifically proven and we routinely prescribe it. There are many drugs like Liv 52 (arrests the progress of cirrhosis and prevents liver damage), Himplasia (treating Benign Prostatic Hyperplasia), Prostina (urinary infection medicine) , Abana (lowers bad cholesterol levels & restores good cholesterol levels) that are routinely prescribed by allopathic doctors. CoroQuil-Zn is backed by science. The advisors are world renowned pharmacologists and virologists. They include Dr. Kamalendra Singh, University of Missouri; Dr. Ramesh Goyal, DPSRU, Dr. Subbu Apparsundaram, DPSRU and Dr. Pavithra Venkatagopalan, Virologist.
Developing a synthetic drug for any drug targets takes an average of 8 to 10 years. The initial response to a new disease in a pandemic like COVID is to repurpose existing drugs. Our researchers have been studying molecules that arrest the binding of the SARS-COV virus to the ACE2 receptor for the last 15 years. The global pandemic accelerated our efforts to formulate a drug that implements the molecule uncovered by our research. We took the herbal route for the drug since it would allow us to bring a treatment out faster – given that there aren’t any toxicity issues.
ACE2 is a vital element in a biochemical pathway that is critical to regulating processes such as blood pressure, wound healing and inflammation. ACE2 helps modulate the many activities of a protein called angiotensin II. (ANG II) that increases blood pressure and inflammation, increasing damage to blood vessel linings and various types of tissue injury. ACE2 converts ANG II to other molecules that counteract the effects of ANG II. Now, ANG II can increase inflammation and the death of cells in the alveoli which are critical for bringing oxygen into the body; these harmful effects of ANG II are reduced by ACE2. When the SARS CoV-2 virus binds to ACE2, it prevents ACE2 from performing its normal function to regulate ANG II signaling. Thus, ACE2 action is “inhibited,” removing the brakes from ANG II signaling and making more ANG II available to injure tissues.
The earlier drugs that were developed focused on blocking the enzymatic activity. CoroQuil-Zn was developed specifically to arrest the binding of the virus.
ACE2 is a vital element in a biochemical pathway that is critical to regulating processes such as blood pressure, wound healing and inflammation. ACE2 helps modulate the many activities of a protein called angiotensin II. (ANG II) that increases blood pressure and inflammation, increasing damage to blood vessel linings and various types of tissue injury. ACE2 converts ANG II to other molecules that counteract the effects of ANG II. Now, ANG II can increase inflammation and the death of cells in the alveoli which are critical for bringing oxygen into the body; these harmful effects of ANG II are reduced by ACE2. When the SARS CoV-2 virus binds to ACE2, it prevents ACE2 from performing its normal function to regulate ANG II signaling. Thus, ACE2 action is “inhibited,” removing the brakes from ANG II signaling and making more ANG II available to injure tissues.
The earlier drugs that were developed focused on blocking the enzymatic activity. CoroQuil-Zn was developed specifically to arrest the binding of the virus.
13. Medicine has been using ACE inhibitors for quite some time now. Will those be just as effective?
The ACE inhibitor drugs Captopril (to treat high blood pressure and heart failure), Enalapril (treat high blood pressure, diabetic kidney disease, and heart failure) are designed to inhibit ACE (or ACE1),and are useful in controlling blood pressure. The structure of ACE and ACE2 are quite different. So, while Captopril and Enalapril are effective in blocking the ACE enzyme, they cannot block the ACE2 enzyme.
CoroQuil-Zn is formulated using Zinc and only edible plants that are listed in Ayurvedic Pharmacopeia. Although we have not studied drug interactions with CoroQuil-Zn, we do not expect it to interfere with actions of other medications adversely. It is our recommendation that you consult your physician or a qualified healthcare professional for any guidance.
In Clinical Trials, we have tested CoroQuil-Zn in patients 18 year or older. Considering that CoroQuil-Zn contains Zinc and only edible plants that are listed in Ayurvedic Pharmacopeia, lower doses of CoroQuil-Zn ingredients (example half of the capsule content) can be mixed with syrup/honey/sugar or suitable edible sweeteners, and taken orally.
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