It has been established that the binding of the Spike S Protein of the SARS-CoV-2 virus to the host cell’s ACE2 receptor triggers a series of molecular events. This results in the entry of the virus into the host cell. The viral entry activates an immune response in the host to resolve the resulting infection. Depending on the magnitude and duration of the viral load and the time taken by the body to activate the immune response, the SARS-CoV-2 infection may result in asymptomatic / mild / moderate / severe COVID-19 disease. In critically ill patients it may even cause death.
COROQUIL-Zn is designed to counter the binding of the Spike S Protein of the SARS-CoV-2 virus to the ACE2 receptor. Thus the entry of the virus to the host cell is blocked. The formulation of CORORQUIL-Zn is the result of developing a series of cell-based experiments to study the activity of plant extracts. We have also conducted pilot experiments on hamsters. All the pre-clinical laboratory experiments were carried out in collaboration with the University of Missouri, USA.
COVID-19 is a global pandemic caused by the SARS-CoV-2 virus. The virus enters the host epithelial cells of the lungs, gastrointestinal system, blood vessels and other organs via the ACE2 receptors in the cell. The viral entry is followed by viral replication – which leads to dysfunctional immune response and cytokine storm. We used in silico molecular docking and cell-based studies to identify select phytoconstituents, that are present in different plants, for their ability to interfere with the binding of of the virus’ spike S protein’s receptor binding domain (RBD) with the host cell’s ACE2 receptor. We formulated COROQUIL-Zn using these identified plant extracts enriched with active phytoconstituents. By preventing the entry of SARS-COV-2 into the host cell, the viral replication is arrested. This results in the reduction of viral load and, hence, recovery from COVID-19.